Download E-books Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications PDF

By Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)

Growth components are elaborated to regulate the expansion of cells in such physiological methods as wound therapeutic, tissue regeneration and the immune reaction. irregular creation of those progress elements, their receptors or intracellular med!ators in their motion could lead to ailment states together with oncogenesis. This quantity will concentrate on interesting advancements in defining the perfect molecular lesions that let the conversion of managed proliferative signs to neoplasia, at the attainable involvement of progress components within the improvement of blood vessel ailments as visible in diabetes and atherosclerosis, at the altered immune surveillance that ends up in autoimmunity and at the basic mechanisms through which progress components sign their goal cells. we predict that the contents of this quantity can assist advertise knowing of the function of those basic organic approaches and their changes in a large choice of sickness states and stimulate new investi­ gations during this vital region of biomedical study. The Editors v CONTENTS views at the regulate OF development AND DIFFERENTIATION views at the Biology of progress elements . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived progress issue- Its position in health and wellbeing and sickness. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine R. Ross and E. W. Raines Molecular and Developmental Biology points of Fibroblast development issue. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical homes of Human Angiogenin. . . . . . . . . . forty-one B. L. Vallee and J. F. Riordan development issue - ONCOGENE RELATIONSHIPS constitution - functionality Relationships in mobile and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . fifty five T. Pawson. P. Greer, M. Moran, K.

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